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Review
. 2009 Feb;29(2):221-3.
doi: 10.1038/jcbfm.2008.101. Epub 2008 Sep 17.

Reprint: Good laboratory practice: preventing introduction of bias at the bench

Malcolm R Macleod  1 , Marc Fisher, Victoria O'Collins, Emily S Sena, Ulrich Dirnagl, Philip M W Bath, Alastair Buchan, H Bart van der Worp, Richard J Traystman, Kazuo Minematsu, Geoffrey A Donnan, David W Howells
Affiliations
Review

Reprint: Good laboratory practice: preventing introduction of bias at the bench

Malcolm R Macleod et al. J Cereb Blood Flow Metab. 2009 Feb.

Erratum in

  • J Cereb Blood Flow Metab. 2009 Jun;29(6):1226. Buchan, Alistair [corrected to Buchan, Alastair]

Abstract

As a research community, we have failed to show that drugs, which show substantial efficacy in animal models of cerebral ischemia, can also improve outcome in human stroke. Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct, and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective efficacy. Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal experiments modeling human stroke.

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