Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Dec 15;123(12):2885-90.
doi: 10.1002/ijc.23847.

Prenatal and perinatal risk factors for neuroblastoma

Elizabeth Bluhm  1 , Dawn Elizabeth McNeil, Sven Cnattingius, Gloria Gridley, Laure El Ghormli, Joseph F Fraumeni Jr
Affiliations

Prenatal and perinatal risk factors for neuroblastoma

Elizabeth Bluhm et al. Int J Cancer. .

Abstract

Neuroblastoma is a rare embryonal tumor of childhood for which risk factors are not well known. Using a nested case-control design, we investigated prenatal, perinatal and neonatal risk factors in detail by linking 245 pediatric neuroblastoma cases identified in the Swedish Cancer Register diagnosed in the year 1973-1995 with the Swedish Medical Birth Register. Five living controls per case were randomly selected from the birth registry, matched by gender and age. Increased risks were associated with maternal anemia during pregnancy (odds ratio (OR) = 2.95, 95% confidence interval (CI): 1.53, 5.69), neonatal respiratory distress (OR = 3.61, 95% CI: 1.41, 9.24) and low (below or equal to 7) 1-min Apgar score (OR = 2.23, 95% CI: 1.41, 3.52). Increased risks were limited to cases diagnosed before 1 year of age. Markers of prenatal, perinatal and neonatal distress may be associated with neuroblastoma in infancy, but not with diagnoses at 1 year or above.

PubMed Disclaimer

References

    1. Brodeur G, Maris J. Neuroblastoma. 4. Philadelphia: Lippincott Williams & Wilkins; 2002.
    1. Goodman MT, Goodman GJ, Smith MA, Olshan AF. Sympathetic Nervous System Tumors. Bethesda, MD: National Cancer Institute; 1999.
    1. Attiyeh EF, London WB, Mosse YP, Wang Q, Winter C, Khazi D, McGrady PW, Seeger RC, Look AT, Shimada H, Brodeur GM, Cohn SL, et al. Chromosome 1p and 11q deletions and outcome in neuroblastoma. N Engl J Med. 2005;353(21):2243–53. - PubMed
    1. Brodeur GM. Neuroblastoma: biological insights into a clinical enigma. Nat Rev Cancer. 2003;3(3):203–16. - PubMed
    1. Narod SA, Stiller C, Lenoir GM. An estimate of the heritable fraction of childhood cancer. Br J Cancer. 1991;63(6):993–9. - PMC - PubMed

Publication types

MeSH terms