Coordinating development of medullary thymic epithelial cells
- PMID: 18799147
- DOI: 10.1016/j.immuni.2008.09.001
Coordinating development of medullary thymic epithelial cells
Abstract
Three papers in this issue of Immunity (Akiyama et al., 2008; Hikosaka et al., 2008; Irla et al., 2008) together reveal coordinating roles for autoreactive T cells and TNF receptor superfamily members in the development of medullary thymic epithelial cells.
Comment on
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The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.Immunity. 2008 Sep 19;29(3):423-37. doi: 10.1016/j.immuni.2008.06.015. Immunity. 2008. PMID: 18799149
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The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.Immunity. 2008 Sep 19;29(3):438-50. doi: 10.1016/j.immuni.2008.06.018. Immunity. 2008. PMID: 18799150
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Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity.Immunity. 2008 Sep 19;29(3):451-63. doi: 10.1016/j.immuni.2008.08.007. Immunity. 2008. PMID: 18799151
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