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. 2009 Apr;41(4):277-82.
doi: 10.1016/j.dld.2008.07.312. Epub 2008 Sep 16.

Effects of dual pulse gastric electrical stimulation on gastric tone and compliance in dogs

Y Lei  1 , J D Z Chen
Affiliations

Effects of dual pulse gastric electrical stimulation on gastric tone and compliance in dogs

Y Lei et al. Dig Liver Dis. 2009 Apr.

Abstract

Background: Gastric electrical stimulation (GES) with short pulses improves nausea and vomiting in patients with gastroparesis, whereas GES with long pulses improves gastric motility.

Aims: To assess the effects of a novel method of GES using dual pulse (both short and long pulses) on gastric tone, compliance and sympathovagal activity in dogs.

Materials and methods: The study was performed in 7 dogs implanted with a gastric cannula and a pair of gastric serosal electrodes for dual pulse GES. The study was composed of a number of sessions on different days with different stimulation parameters, including variations in the number of short pulses and stimulation amplitude.

Results: (1) Dual pulse GES of one short pulse and one long pulse with various amplitudes inhibited gastric tone (p<0.05) but did not alter sympathetic or vagal activity. (2) Dual pulse GES with five short pulses and one long pulse not only inhibited gastric tone, but also reduced sympathetic activity and increased vagal activity (p<0.05). (3) Dual pulse GES with five short pulses and one long pulse significantly increased gastric compliance.

Conclusions: Dual pulse GES reduces gastric tone and increases gastric compliance. The variation in the number of short pulse affects the sympathetic and vagal activities, whereas, the increase in stimulation strength enhances its effects on gastric tone.

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Figures

Fig. 1
Fig. 1
A. One short pulse (0.3ms) followed with a long pulse (400ms) with an interval of 100ms between the short pulse and long pulse, amplitude of 2mA and repeated at the frequency of the intrinsic gastric slow waves. B. Increase the number of short pulse to five (width of 0.3ms, frequency of 40 Hz). The interval between the last short pulse and the long pulse was 100ms.
Fig. 2
Fig. 2
Dual pulse GES with variation of amplitudes significantly induced the proximal gastric volume increase, which was gastric tone decrease. *p<0.05 vs Baseline.
Fig. 3
Fig. 3
The effect of dual pulse GES on gastric compliance (mean±SE). Dual pulse induced a significantly increase in gastric compliance compared with without dual pulse GES (*p<0.01).
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