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Comparative Study
. 1991 Sep;59(9):3291-6.
doi: 10.1128/iai.59.9.3291-3296.1991.

Growth of Francisella spp. in rodent macrophages

L D Anthony  1 , R D Burke, F E Nano
Affiliations
Comparative Study

Growth of Francisella spp. in rodent macrophages

L D Anthony et al. Infect Immun. 1991 Sep.

Abstract

We examined the nature of the interactions between the facultative intracellular pathogens Francisella tularensis and F. novicida and rodent macrophages. Growth of F. tularensis LVS was observed in macrophage monolayers from mice, guinea pigs, or rats. In contrast, F. novicida grew in macrophages from mice and guinea pigs but not in macrophages from rats. Transmission electron microscopy studies indicated that both Francisella species survive within macrophage phagosomes that are unfused with lysosomes.

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