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. 1976 Nov;3(11):3227-33.
doi: 10.1093/nar/3.11.3227.

Excision in vitro of the DNA bound carcinogen, 4-nitroquinoline 1-oxide

S Yoshida, M Tada, M Tada
Free PMC article

Excision in vitro of the DNA bound carcinogen, 4-nitroquinoline 1-oxide

S Yoshida et al. Nucleic Acids Res. 1976 Nov.
Free PMC article

Abstract

It has been shown that 4-hydroxyaminoquinoline 1-oxide, the proximate form of the carcinogen 4-nitroquinoline 1-oxide, binds covalently to the purine bases of DNA. Here we report that carcinogen-bound nucleotides can be excised from DNA by a 5' leads to 3' exonuclease associated with DNA polymerase I of E. coli in the forms of either mononucleotides or oligonucleotides. Beef spleen phosphodiesterase II (5' leads to 3') also split carcinogen-bound nucleotides, while a 3' leads to 5' exonuclease of DNA polymerase I and E. coli exonuclease III (3' leads to 5') could not excise the modified nucleotide.

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