Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Nov 1;56(14):1532-1540.
doi: 10.1002/glia.20750.

Molecular domains of myelinated axons in the peripheral nervous system

James L Salzer  1 , Peter J Brophy  2 , Elior Peles  3
Affiliations
Review

Molecular domains of myelinated axons in the peripheral nervous system

James L Salzer et al. Glia. .

Abstract

Myelinated axons are organized into a series of specialized domains with distinct molecular compositions and functions. These domains, which include the node of Ranvier, the flanking paranodal junctions, the juxtaparanodes, and the internode, form as the result of interactions with myelinating Schwann cells. This domain organization is essential for action potential propagation by saltatory conduction and for the overall function and integrity of the axon.

PubMed Disclaimer

References

REFERENCES

    1. Abe I,Ochiai N,Ichimura H,Tsujino A,Sun J,Hara Y. 2004. Internodes can nearly double in length with gradual elongation of the adult rat sciatic nerve. J Orthop Res 22: 571-577.
    1. Arimura K,Sonoda Y,Watanabe O,Nagado T,Kurono A,Tomimitsu H,Otsuka R,Kameyama M,Osame M. 2002. Isaacs' syndrome as a potassium channelopathy of the nerve. Muscle Nerve Suppl 11: S55-S58.
    1. Averill S,Robson LG,Jeromin A,Priestley JV. 2004. Neuronal calcium sensor-1 is expressed by dorsal root ganglion cells, is axonally transported to central and peripheral terminals, and is concentrated at nodes. Neuroscience 123: 419-427.
    1. Banerjee S,Sousa AD,Bhat MA. 2006. Organization and function of septate junctions: An evolutionary perspective. Cell Biochem Biophys 46: 65-77.
    1. Bennett V,Baines AJ. 2001. Spectrin and ankyrin-based pathways: Metazoan inventions for integrating cells into tissues. Physiol Rev 81: 1353-1392.

Publication types

MeSH terms

Substances

LinkOut - more resources