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. 2009 Dec;182(3):474-80.
doi: 10.1016/j.tvjl.2008.08.001. Epub 2008 Sep 19.

Serological and molecular evidence of hepatitis E virus in swine in Brazil

Debora Regina Lopes dos Santos  1 , Claudia Lamarca Vitral, Vanessa Salete de Paula, Renato Sergio Marchevsky, Juliana Freitas Lopes, Ana Maria Coimbra Gaspar, Telma Michella Saddi, Nilton Cecílio de Mesquita Júnior, Flavio de Rezende Guimarães, João Garcia Caramori Júnior, Lia Laura Lewis Ximenes, Francisco José Dutra Souto, Marcelo Alves Pinto
Affiliations

Serological and molecular evidence of hepatitis E virus in swine in Brazil

Debora Regina Lopes dos Santos et al. Vet J. 2009 Dec.

Abstract

Active hepatitis E virus (HEV) infections in two Brazilian swine herds were investigated. In study 1, 26 piglets born to five anti-HEV positive sows were monitored from birth to post-partum week 22. Serum samples were screened for the detection of anti-HEV antibodies and a nested RT-PCR used to examine the HEV genome. Passive transfer of immunity was confirmed. At week 22, 23/26 (88.4%) of the piglets had seroconverted. Genome amplification was achieved in a feces pool from one holding pen and in one serum sample, both from 13-week-old animals. Histology was suggestive of a potential HEV infection. In the second study, 47 piglets born to six anti-HEV-positive sows were monitored after weaning. Seroconversion was determined in eight animals at 6-8 weeks of age. HEV RNA was detected in two pools from a holding pen for 12-16-week-old animals. Brazilian isolates were classified as genotype 3. This is the first molecular evidence of HEV infection in Brazilian pig herds.

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