Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Oct 15;582(23-24):3537-41.
doi: 10.1016/j.febslet.2008.09.025. Epub 2008 Sep 19.

In HspA from Helicobacter pylori vicinal disulfide bridges are a key determinant of domain B structure

Salvatore Loguercio  1 , Cyril Dian, Angela Flagiello, Alessandra Scannella, Piero Pucci, Laurent Terradot, Adriana Zagari
Affiliations
Free article

In HspA from Helicobacter pylori vicinal disulfide bridges are a key determinant of domain B structure

Salvatore Loguercio et al. FEBS Lett. .
Free article

Abstract

Helicobacter pylori produces a heat shock protein A (HspA) that is unique to this bacteria. While the first 91 residues (domain A) of the protein are similar to GroES, the last 26 (domain B) are unique to HspA. Domain B contains eight histidines and four cysteines and was suggested to bind nickel. We have produced HspA and two mutants: Cys94Ala and Cys94Ala/Cys111Ala and identified the disulfide bridge pattern of the protein. We found that the cysteines are engaged in three disulfide bonds: Cys51/Cys53, Cys94/Cys111 and Cys95/Cys112 that result in a unique closed loop structure for the domain B.

PubMed Disclaimer

Publication types

LinkOut - more resources