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. 2009 Jan;36(1):48-52.
doi: 10.1007/s00259-008-0944-5. Epub 2008 Sep 20.

Correlation of immunohistopathological expression of somatostatin receptor 2 with standardised uptake values in 68Ga-DOTATOC PET/CT

Matthias Miederer  1 , Stefan Seidl, Andreas Buck, Klemens Scheidhauer, Hans-Jürgen Wester, Markus Schwaiger, Aurel Perren
Affiliations
Free article

Correlation of immunohistopathological expression of somatostatin receptor 2 with standardised uptake values in 68Ga-DOTATOC PET/CT

Matthias Miederer et al. Eur J Nucl Med Mol Imaging. 2009 Jan.
Free article

Abstract

Purpose: In clinical routine somatostatin analogue positron emission tomography/computed tomography (PET/CT) such as (68)Ga-DOTA-Tyr-octreotide (DOTATOC)-PET/CT could substitute conventional (111)In-Octreotide scintigraphy. Immunohistochemistry (IHC) for somatostatin receptor 2 (SSTR2) might be a tool to predict positivity of (68)Ga-DOTATOC in patients where initial staging was not performed, e.g., in incidental findings. We therefore compared a score of SSTR2-IHC with the in vivo standard uptake value (SUV) of preoperative or prebiopsy (68)Ga-DOTATOC PET/CT.

Materials and methods: In 18 patients, (68)Ga-DOTATOC PET/CT scans were quantified with SUV calculations and correlated to a cell membrane-based SSTR2-IHC score (ranging from 0 to 3).

Results: Negative IHC scores were consistent with SUV values below 10. Furthermore, all score 2 and 3 specimens corresponded with high SUV values (above 15).

Conclusion: SSTR2-IHC scores correlated well with SUV values and we propose to use SSTR2 immunohistochemistry in patients missing a preoperative PET scan to indicate (68)Ga-DOTATOC-PET/CT as method for restaging and follow-up in individual patients.

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References

    1. Eur J Nucl Med Mol Imaging. 2007 Oct;34(10 ):1617-26 - PubMed
    1. J Nucl Med. 2005 Jan;46 Suppl 1:76S-82S - PubMed
    1. J Clin Oncol. 2008 Feb 20;26(6):963-70 - PubMed
    1. Mod Pathol. 2007 Nov;20(11):1172-82 - PubMed
    1. Eur Radiol. 1997;7(7):1103-9 - PubMed

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