Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2008 Oct 1;112(7):2598-9.
doi: 10.1182/blood-2008-07-165688.

Polyphosphate: physiologic? Pathologic? Pharmacologic?

Alisa S Wolberg  1
Affiliations
Comment

Polyphosphate: physiologic? Pathologic? Pharmacologic?

Alisa S Wolberg. Blood. .

Abstract

Polyphosphate, a linear polymer of inorganic phosphate found in bacteria, fungi, plants, and recently, human platelets, enhances fibrin clot structure and stability and may play a central role in both normal and pathologic coagulation.

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest disclosure: The author declares no competing financial interests. ■

Figures

None
Potential roles for polyP in hemostasis and thrombosis. Illustration by Marie Dauenheimer.
See this image and copyright information in PMC

Comment on

References

    1. Wolberg AS. Thrombin generation and fibrin clot structure. Blood Rev. 2007;21:131–142. - PubMed
    1. Collet JP, Montalescot G, Lesty C, et al. Effects of Abciximab on the architecture of platelet-rich clots in patients with acute myocardial infarction undergoing primary coronary intervention. Circulation. 2001;103:2328–2331. - PubMed
    1. Collet JP, Montalescot G, Lesty C, et al. Disaggregation of in vitro preformed platelet-rich clots by abciximab increases fibrin exposure and promotes fibrinolysis. Arterioscler Thromb Vasc Biol. 2001;21:142–148. - PubMed
    1. Collet JP, Montalescot G, Lesty C, Weisel JW. A structural and dynamic investigation of the facilitating effect of glycoprotein IIb/IIIa inhibitors in dissolving platelet-rich clots. Circ Res. 2002;90:428–434. - PubMed
    1. Campbell RA, Overmyer KA, Bagnell CR, Wolberg AS. Cellular procoagulant activity dictates clot structure as a function of distance from the cell surface. Arterio Thromb Vasc Biol. 2008:P186. - PMC - PubMed