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. 2008 Nov 6;10(21):4735-8.
doi: 10.1021/ol801791g. Epub 2008 Sep 25.

Synthesis of D- and L-carbocyclic nucleosides via rhodium-catalyzed asymmetric hydroacylation as the key step

Patricia Marcé  1 , Yolanda Díaz, M Isabel Matheu, Sergio Castillón
Affiliations

Synthesis of D- and L-carbocyclic nucleosides via rhodium-catalyzed asymmetric hydroacylation as the key step

Patricia Marcé et al. Org Lett. .

Abstract

D- and L-carbocyclic nucleosides were obtained by a new procedure involving an enantioselective rhodium/duphos-catalyzed hydroacylation reaction as the key step. The 3-hydroxymethyl-cyclopentanol intermediate was obtained by stereoselective reduction of ketone and by dynamic kinetic resolution (DKR).

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