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. 2008 Sep 23;6(9):e237.
doi: 10.1371/journal.pbio.0060237.

It's not how fat you are, it's what you do with it that counts

Samuel Virtue  1 , Antonio Vidal-Puig
Affiliations

It's not how fat you are, it's what you do with it that counts

Samuel Virtue et al. PLoS Biol. .

Abstract

Mechanisms underlying obesity-related metabolic disorders are poorly understood. Samuel Virtue and Antonio Vidal-Puig explore the evidence for an emerging hypothesis that attributes metabolic complications not to obesity per se, but to an individual's capacity for adipose tissue expandability.

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Figures

Figure 1
Figure 1. Insulin Sensitivity
(A) Diagram showing the different models of how weight loss affects insulin sensitivity within an individual. (B) Diagram showing how multiple individuals with sigmoid responses in insulin sensitivity can add to form a linear alteration in insulin sensitivity across a population.
See this image and copyright information in PMC

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