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Comparative Study
. 2008 Sep;15(6):291-4.
doi: 10.1155/2008/697186.

Sex disparities in effects of cystic fibrosis-related diabetes on clinical outcomes: a matched study

R J Miller  1 , H D Tildesley, P G Wilcox, H Zhang, S H Kreisman
Affiliations
Comparative Study

Sex disparities in effects of cystic fibrosis-related diabetes on clinical outcomes: a matched study

R J Miller et al. Can Respir J. 2008 Sep.

Abstract
in English, French

Background: Cystic fibrosis-related diabetes (CFRD) is an increasingly prevalent comorbidity factor for patients with cystic fibrosis (CF). CFRD has been associated with an accelerated decline in clinical parameters and an increased mortality rate.

Objectives: To investigate the clinical impact of CFRD on pulmonary function and clinical status using a matched study design to further explore potential causality.

Methods: Charts from the adult CF clinic at St Paul's Hospital (Vancouver, British Columbia) were retrospectively reviewed. Forty CFRD patients with and without fasting hyperglycemia were matched to CF patients with nondiabetic glucose tolerance based on sex, age and forced expiratory volume in 1 s (FEV(1)).

Results: Sixteen of 40 CFRD patients (40%) died compared with nine of 40 patient controls (23%) (P=0.13). CFRD patients were more likely to experience declines in FEV(1) (P<0.01), especially women (P<0.01). Patients with CFRD were not more likely to be hospitalized (P=0.39). Body mass index did not differ between groups.

Conclusions: Patients with CFRD had higher rates of FEV(1) deterioration than nondiabetic patients with CF, and showed a trend toward increased mortality. The present study suggests that CFRD has a significant clinical impact and should be carefully considered when evaluating the status of CF patients.

HISTORIQUE :: Le diabète lié à la fibrose kystique (DLFK) est un facteur de comorbidité de plus en plus prévalent pour les patients atteints de fibrose kystique (FK). Le DLFK s’associe à une détérioration accélérée des paramètres cliniques et à une augmentation du taux de mortalité.

OBJECTIFS :: Explorer les répercussions cliniques du DLFK sur la fonction pulmonaire et l’état clinique au moyen d’une étude appariée pour évaluer la causalité potentielle de manière approfondie.

MÉTHODOLOGIE :: Les dossiers de la clinique de FK pour adultes du St. Paul Hospital (de Vancouver, en Colombie-Britannique) ont fait l’objet d’une étude prospective. Quarante patients atteints de DLFK présentant ou non de l’hyperglycémie à jeun ont été appariés à des patients atteints de DLFK ayant une tolérance au glucose non diabétique d’après le sexe, l’âge et le volume expiratoire maximal par seconde (VEMS).

RÉSULTATS :: Seize des 40 patients atteints de DLFK (40 %) sont décédés par rapport à neuf des 40 sujets témoins (23 %) (P=0,13). Les patients atteints de DLFK étaient plus susceptibles de présenter une diminution du VEMS (P<0,01), notamment les femmes (P<0,01). Les patients atteints de DLFK ne couraient pas plus de risque d’être hospitalisés (P=0,39). L’indice de masse corporelle ne différait pas entre les groupes.

CONCLUSIONS :: Les patients atteints d’un DLFK présentaient des taux de détérioration du VEMS plus élevés que les patients atteints de FK non diabétique et révélaient une tendance vers une mortalité accrue. Selon la présente étude, le DLFK a des répercussions cliniques importantes et devrait être soumis à un examen attentif au moment d’évaluer l’état des patients atteints de FK.

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Figures

Figure 1)
Figure 1)
Mean forced expiratory volume in 1 s (FEV1) over time with standard error. CFRD Cystic fibrosis-related diabetes
Figure 2)
Figure 2)
Forced expiratory volume in 1 s (FEV1) over time according to sex, with standard error. CFRD Cystic fibrosis-related diabetes
Figure 3)
Figure 3)
Mean number of hospitalizations per year with standard error. CFRD Cystic fibrosis-related diabetes
See this image and copyright information in PMC

References

    1. Brennan AL, Geddes DM, Gyi KM, Baker EH. Clinical importance of cystic fibrosis-related diabetes. J Cyst Fibros. 2004;3:209–22. - PubMed
    1. Canadian Cystic Fibrosis Foundation . Report of the Canadian Patient Data Registry. Toronto: Canadian Cystic Fibrosis Foundation; 2002.
    1. Lanng S, Thorsteinsson B, Lund-Andersen C, Nerup J, Schiøtz PO, Koch C. Diabetes mellitus in Danish cystic fibrosis patients: Prevalence and late diabetic complications. Acta Paediatr. 1994;83:72–7. - PubMed
    1. Koch C, Rainisio M, Madessani U, et al. Presence of cystic fibrosis-related diabetes mellitus is tightly linked to poor lung function in patients with cystic fibrosis: Data from the European Epidemiologic Registry of Cystic Fibrosis. Pediatr Pulmonol. 2001;32:343–50. - PubMed
    1. Mackie AD, Thornton SJ, Edenborough FP. Cystic fibrosis-related diabetes. Diabet Med. 2003;20:425–36. - PubMed

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