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Randomized Controlled Trial
. 2009 Jan;202(1-3):531-9.
doi: 10.1007/s00213-008-1337-y. Epub 2008 Sep 26.

Methylphenidate improves response inhibition but not reflection-impulsivity in children with attention deficit hyperactivity disorder (ADHD)

Elise E DeVito  1 , Andrew D Blackwell, Luke Clark, Lindsey Kent, Anna Maria Dezsery, Danielle C Turner, Michael R F Aitken, Barbara J Sahakian
Affiliations
Randomized Controlled Trial

Methylphenidate improves response inhibition but not reflection-impulsivity in children with attention deficit hyperactivity disorder (ADHD)

Elise E DeVito et al. Psychopharmacology (Berl). 2009 Jan.

Abstract

Rationale: Impulsivity is a cardinal feature of attention deficit hyperactivity disorder (ADHD), which is thought to underlie many of the cognitive and behavioural symptoms associated with the disorder. Impairments on some measures of impulsivity have been shown to be responsive to pharmacotherapy. However, impulsivity is a multi-factorial construct and the degree to which different forms of impulsivity contribute to impairments in ADHD or respond to pharmacological treatments remains unclear.

Objectives: The aims of the study were to assess the effects of methylphenidate (MPH) on the performance of children with ADHD on measures of reflection-impulsivity and response inhibition and to compare with the performance of healthy volunteers.

Methods: Twenty-one boys (aged 7-13 years) diagnosed with ADHD underwent a double-blind, placebo-controlled trial of MPH (0.5 mg/kg) during which they performed the Information Sampling Task (IST) and the Stop Signal Task. A healthy age- and education-matched control group was tested on the same measures without medication.

Results: Children with ADHD were impaired on measures of response inhibition, but did not demonstrate reflection-impulsivity on the IST. However, despite sampling a similar amount of information as their peers, the ADHD group made more poor decisions. MPH improved performance on measures of response inhibition and variability of response, but did not affect measures of reflection-impulsivity or quality of decision-making.

Conclusions: MPH differentially affected two forms of impulsivity in children with ADHD and failed to ameliorate their poor decision-making on the information sampling test.

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Figures

Fig. 1
Fig. 1
Group and drug effects on IST poor decisions and SST SSRT
Fig. 2
Fig. 2
More uncertainty tolerated prior to decision-making associated with self-rated impulsivity in ADHD-placebo
Fig. 3
Fig. 3
Self-rated empathy not impulsivity associated with behaviour ratings
See this image and copyright information in PMC

Comment in

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