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Review
. 2008 Dec;9(6):321-2.
doi: 10.1080/17482960802425559.

Is it too soon for mesenchymal stem cell trials in people with ALS?

Irina Badayan  1 , Merit E Cudkowicz
Affiliations
Review

Is it too soon for mesenchymal stem cell trials in people with ALS?

Irina Badayan et al. Amyotroph Lateral Scler. 2008 Dec.

Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting primarily the motor neurons. Stem cell therapy is under development as a possible treatment approach. A pilot study of intraspinal injections of mesenchymal stem cells (MSC) was conducted in 9 participants. We review this paper, the rationale, preclinical data and study design.

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Comment in

  • Mesenchymal stem cells for ALS patients.
    Mazzini L, Vercelli A, Mareschi K, Ferrero I, Testa L, Fagioli F. Mazzini L, et al. Amyotroph Lateral Scler. 2009 Apr;10(2):123-4. doi: 10.1080/17482960802572707. Amyotroph Lateral Scler. 2009. PMID: 19085190 No abstract available.

Comment on

  • Stem cell treatment in Amyotrophic Lateral Sclerosis.
    Mazzini L, Mareschi K, Ferrero I, Vassallo E, Oliveri G, Nasuelli N, Oggioni GD, Testa L, Fagioli F. Mazzini L, et al. J Neurol Sci. 2008 Feb 15;265(1-2):78-83. doi: 10.1016/j.jns.2007.05.016. Epub 2007 Jun 19. J Neurol Sci. 2008. PMID: 17582439 Clinical Trial.

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