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. 2008 Nov;43(3):328-9.
doi: 10.1016/j.jcv.2008.08.002. Epub 2008 Sep 25.

Reactivation of Polyomavirus hominis 1 (BKV) during pregnancy and the risk of mother-to-child transmission

Zlatko Kalvatchev  1 , Svetoslav Slavov, Milkana Shtereva, Silvia Savova
Affiliations

Reactivation of Polyomavirus hominis 1 (BKV) during pregnancy and the risk of mother-to-child transmission

Zlatko Kalvatchev et al. J Clin Virol. 2008 Nov.

Abstract

Background: Pregnancy is associated with down-regulation of immune responses of the mother. This might lead to reactivation and vertical transmission of latent viral infections such as BK virus (BKV).

Objectives: To determine the presence of BKV in the urine of pregnant women and in cord blood at delivery.

Study design: We examined urines from 52 pregnant women and 51 cord blood samples for BKV by real-time SYBR green PCR.

Results: BKV DNA was found in the urine of 18 (34.6%) pregnant women. No BKV DNA was detected by SYBR green PCR in the cord blood specimens.

Conclusions: BKV reactivation is common during pregnancy but this is not associated with BKV in cord blood.

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