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Comparative Study
. 1991;104(1):57-61.
doi: 10.1007/BF02244554.

Reduction of oxotremorine-induced analgesia after chronic but not acute restraint stress

A Badiani  1 , F Pavone
Affiliations
Comparative Study

Reduction of oxotremorine-induced analgesia after chronic but not acute restraint stress

A Badiani et al. Psychopharmacology (Berl). 1991.

Abstract

The analgesic response (tail-flick latency) induced by the muscarinic cholinergic agonist oxotremorine was investigated in DBA/2 mice exposed to acute (a single 2 h session) and chronic (2 h once daily for 10 days) restraint stress. While a single exposure to stress did not influence the antinociceptive effects of the cholinergic agonist, chronic stress induced a clear-cut reduction of the oxotremorine-induced analgesia. The results show an involvement of cholinergic mechanisms in the adaptive modulation of nociception after chronic stressful events.

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