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. 2008 Sep;4(3):149-50.
doi: 10.1007/BF03161192.

Four-year experience with methotrexate exposures

Frank LoVecchio  1 , Kenneth Katz, David Watts, Ian Wood
Affiliations

Four-year experience with methotrexate exposures

Frank LoVecchio et al. J Med Toxicol. 2008 Sep.

Abstract

Introduction: Unintentional methotrexate (MTX) acute oral overdose is rarely reported.

Methods: We conducted a retrospective chart review of all human exposure calls (>150,000 charts) for MTX ingestions reported to our Poison Center during 2000-2003.

Results: Thirteen patients met the criteria. The average amount of MTX ingested was 13.03 mg (data from 7 cases), and the average patient age was 43 years (20 months to 80 years). No significant toxicities occurred.

Discussion: Although intravenous MTX toxicity can be severe, this does not appear to be a phenomenon associated with either acute unintentional or suicidal oral ingestion.

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