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. 2008 Sep 26:8:19.
doi: 10.1186/1471-2466-8-19.

Early intestinal Bacteroides fragilis colonisation and development of asthma

Carl Vael  1 , Vera Nelen, Stijn L Verhulst, Herman Goossens, Kristine N Desager
Affiliations

Early intestinal Bacteroides fragilis colonisation and development of asthma

Carl Vael et al. BMC Pulm Med. .

Abstract

Background: The 'hygiene hypothesis' suggests that early exposure to microbes can be protective against atopic disease. The intestinal microbial flora could operate as an important postnatal regulator of the Th1/Th2 balance. The aim of the study was to investigate the association between early intestinal colonisation and the development of asthma in the first 3 years of life.

Methods: In a prospective birth cohort, 117 children were classified according to the Asthma Predictive Index. A positive index included wheezing during the first three years of life combined with eczema in the child in the first years of life or with a parental history of asthma. A faecal sample was taken at the age of 3 weeks and cultured on selective media.

Results: Asthma Predictive Index was positive in 26/117 (22%) of the children. The prevalence of colonisation with Bacteroides fragilis was higher at 3 weeks in index+ compared to index- children (64% vs. 34% p < 0,05). Bacteroides fragilis and Total Anaerobes counts at 3 weeks were significantly higher in children with a positive index as compared with those without. After adjusting for confounders a positive association was found between Bacteroides fragilis colonisation and Asthma Predictive Index (odds ratio: 4,4; confidence interval: 1,7 - 11,8).

Conclusion: Bacteroides fragilis colonisation at age 3 weeks is an early indicator of possible asthma later in life. This study could provide the means for more accurate targeting of treatment and prevention and thus more effective and better controlled modulation of the microbial milieu.

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References

    1. Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ. Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med. 1995;332:133–138. doi: 10.1056/NEJM199501193320301. - DOI - PubMed
    1. Strachan DP. Hay fever, hygiene, and household size. BMJ. 1989;299:1259–1260. - PMC - PubMed
    1. Murch SH. The immunologic basis for intestinal food allergy. Curr Opin Gastroenterol. 2000;16:552–557. doi: 10.1097/00001574-200011000-00016. - DOI - PubMed
    1. Miettinen M, Lehtonen A, Julkunen I, Matikainen S. Lactobacilli and Streptococci activate NF-kappa B and STAT signaling pathways in human macrophages. J Immunol. 2000;164:3733–3740. - PubMed
    1. Kalliomaki M, Kirjavainen P, Eerola E, Kero P, Salminen S, Isolauri E. Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing. J Allergy Clin Immunol. 2001;107:129–134. doi: 10.1067/mai.2001.111237. - DOI - PubMed

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