Monitoring of cadmium, copper, lead and zinc status in young children using toenails: comparison with scalp hair

Abstract

Cadmium, copper, lead and zinc concentrations were determined (atomic absorption spectrometry) in the proximal end of scalp hair (n = 474) and in toenail clippings (n = 461) of children, aged 3-7 years, living in an industrialized and in a rural area of the Federal Republic of Germany. With the exception of Zn in hair, levels of the elements were log-normally distributed. Data are presented as geometric means. Toenail Cd and Pb levels were much higher than those in hair (Cd, 457 vs 90 ng g-1; Pb, 8.5 vs 2.7 micrograms g-1), while Cu and Zn values were similar in both biological media (toenail vs hair: Cu, 7.5 vs 10.6 micrograms g-1; Zn, 129 vs 108 micrograms g-1). In toenails, all elements were positively correlated with each other. In hair, there was a close relationship only between Cd and Pb; Cd and Pb were inversely related to Zn. With the exception of Zn (no correlation), there was a minor relationship between metal levels in hair and those in toenails. Using stepwise regression analysis, seasonal variation was found to be the main factor influencing hair metal levels, while nail metal levels were mainly influenced by place of residence (with the exception of Cu concentrations, for which there were no significant predictors). Multiple correlation coefficient was higher for hair than for nails. It is concluded that, for biological monitoring, toenail clippings are less suitable than hair samples.