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Review
. 1991 May;16(5):187-90.
doi: 10.1016/0968-0004(91)90073-5.

Who's on first? The U1 snRNP-5' splice site interaction and splicing

M Rosbash  1 , B Séraphin
Affiliations
Review

Who's on first? The U1 snRNP-5' splice site interaction and splicing

M Rosbash et al. Trends Biochem Sci. 1991 May.

Abstract

U1 small nuclear ribonucleoprotein (snRNP) is important for pre-mRNA splicing both in yeast (Saccharomyces cerevisiae) and mammalian systems. The RNA component of U1 snRNP, U1 snRNA, interacts by base pairing with pre-mRNA 5' splice sites. This article examines recent evidence suggesting that U1 snRNP is important for an early step in spliceosome assembly rather than a late step that contributes to the specificity of 5' splice-site cleavage.

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