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Review
. 2008:421:1-21.

Affinity chromatography: history, perspectives, limitations and prospects

Ana Cecília A Roque  1 , Christopher R Lowe
Affiliations
  • PMID: 18826044
Review

Affinity chromatography: history, perspectives, limitations and prospects

Ana Cecília A Roque et al. Methods Mol Biol. 2008.

Abstract

Biomolecule separation and purification has until very recently steadfastly remained one of the more empirical aspects of modem biotechnology. Affinity chromatography, one of several types of adsorption chromatography, is particularly suited for the efficient isolation of biomolecules. This technique relies on the adsorbent bed material that has biological affinity for the substance to be isolated. This review is intended to place affinity chromatography in historical perspective and describe the current status, limitations and future prospects for the technique in modern biotechnology.

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