Targeting the mammalian target of rapamycin in myxoid chondrosarcoma

Abstract

Myxoid chondrosarcoma is a slow-growing sarcoma poorly responsive to chemotherapy and radiation therapy. Translational research has validated several proteins as optional therapeutic targets. Significant responses are, however, rare. In this paper we report an extraordinary response of myxoid chondrosarcoma to targeted therapy by rapamycin in combination with cyclophosphamide. Our case points to a possible novel therapeutic approach towards myxoid chondrosarcoma, by targeting the mammalian target of rapamycin protein, and probably protein kinase C-alpha, mitogen-activated protein kinase, and Jun N-terminal kinase too, by rapamycin.