Tolerance to self: which cells kill?
- PMID: 18828676
- PMCID: PMC2553847
- DOI: 10.1371/journal.pbio.0060241
Tolerance to self: which cells kill?
Abstract
Immune self tolerance involves the deletion in the thymus of developing T cells that have the ability to recognize self-antigens, but by which cells? New evidence argues that cortical epithelial cells can induce deletion of self-reactive T cells.
Comment on
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TSCOT+ thymic epithelial cell-mediated sensitive CD4 tolerance by direct presentation.PLoS Biol. 2008 Aug 5;6(8):e191. doi: 10.1371/journal.pbio.0060191. PLoS Biol. 2008. PMID: 18684012 Free PMC article.
References
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