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. 2009 Jul;15(6):414-6.
doi: 10.1016/j.parkreldis.2008.08.004. Epub 2008 Oct 1.

Glucosidase-beta variations and Lewy body disorders

Matthew J Farrer  1 , Lindsey N Williams, Avi A Algom, Jennifer Kachergus, Mary M Hulihan, Owen A Ross, Alex Rajput, Spiridon Papapetropoulos, Deborah C Mash, Dennis W Dickson
Affiliations

Glucosidase-beta variations and Lewy body disorders

Matthew J Farrer et al. Parkinsonism Relat Disord. 2009 Jul.

Abstract

It has been proposed that there is an increased frequency of glucosidase-beta mutations in Lewy body disorders. Our comprehensive DNA sequencing approach found a small number of glucosidase-beta mutations in 101 neuropathologically defined Lewy body disease cases (3%) compared to 99 healthy post-mortem controls (1%); odds ratio 3.0 (95% CI: 0.3-29, p=0.3). All three affected carriers were classified as diffuse Lewy body disease (n=3/50; 6%). Our study suggests glucosidase-beta variants have a limited role in susceptibility to Lewy body disease in North America.

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Conflict of interest statement

Disclosure: The authors report no conflicts of interest.

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