Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Oct 1;28(40):9895-7.
doi: 10.1523/JNEUROSCI.3778-08.2008.

Reactivation in ventral striatum during hippocampal ripples: evidence for the binding of reward and spatial memories?

Omar Jamil Ahmed  1 , James McFarland, Arvind Kumar
Affiliations
Review

Reactivation in ventral striatum during hippocampal ripples: evidence for the binding of reward and spatial memories?

Omar Jamil Ahmed et al. J Neurosci. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Schematic depiction of the main findings of Lansink et al. (2008). The hypothetical activities of four ventral striatal cells (C1–C4) during PRE, RUN, and POST are shown in the left column. The corresponding pairwise correlations are depicted by the thickness of the lines connecting the cells and are shown in the right column. A, During PRE, all four cells fire at a constant rate, and their firing rate does not change during a ripple in the hippocampal local field potential (blue trace). B, During RUN, the reward (indicated by a water drop) elicits strong responses in cells C1 (green), C2 (orange), and C3 (red), but not in cell C4 (blue). Of the three reward cells, only C1 and C2 show the same temporal response to the reward and are thus strongly correlated during the RUN period. C, In POST, all three reward cells (C1–C3) fire preferentially during the hippocampal ripple. However, the two cells that were strongly correlated on the track are the most strongly correlated during POST ripples. Because of the strong correlation of C1 and C2 during both RUN and POST, the EV is high, and the C1/C2 cell pair is said to be strongly reactivated.
See this image and copyright information in PMC

Comment on

References

    1. Diba K, Buzsáki G. Forward and reverse hippocampal place-cell sequences during ripples. Nat Neurosci. 2007;10:1241–1242. - PMC - PubMed
    1. Ji D, Wilson MA. Coordinated memory replay in the visual cortex and hippocampus during sleep. Nat Neurosci. 2007;10:100–107. - PubMed
    1. Lansink CS, Goltstein PM, Lankelma JV, Joosten RN, McNaughton BL, Pennartz CM. Preferential reactivation of motivationally relevant information in the ventral striatum. J Neurosci. 2008;28:6372–6382. - PMC - PubMed
    1. Lee AK, Wilson MA. Memory of sequential experience in the hippocampus during slow wave sleep. Neuron. 2002;36:1183–1194. - PubMed
    1. Louie K, Wilson MA. Temporally structured replay of awake hippocampal ensemble activity during rapid eye movement sleep. Neuron. 2001;29:145–156. - PubMed