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Review
. 2008 Oct 1;28(40):9895-7.
doi: 10.1523/JNEUROSCI.3778-08.2008.

Reactivation in ventral striatum during hippocampal ripples: evidence for the binding of reward and spatial memories?

Omar Jamil Ahmed  1 , James McFarland, Arvind Kumar
Affiliations
Review

Reactivation in ventral striatum during hippocampal ripples: evidence for the binding of reward and spatial memories?

Omar Jamil Ahmed et al. J Neurosci. .
No abstract available

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Figures

Figure 1.
Figure 1.
Schematic depiction of the main findings of Lansink et al. (2008). The hypothetical activities of four ventral striatal cells (C1–C4) during PRE, RUN, and POST are shown in the left column. The corresponding pairwise correlations are depicted by the thickness of the lines connecting the cells and are shown in the right column. A, During PRE, all four cells fire at a constant rate, and their firing rate does not change during a ripple in the hippocampal local field potential (blue trace). B, During RUN, the reward (indicated by a water drop) elicits strong responses in cells C1 (green), C2 (orange), and C3 (red), but not in cell C4 (blue). Of the three reward cells, only C1 and C2 show the same temporal response to the reward and are thus strongly correlated during the RUN period. C, In POST, all three reward cells (C1–C3) fire preferentially during the hippocampal ripple. However, the two cells that were strongly correlated on the track are the most strongly correlated during POST ripples. Because of the strong correlation of C1 and C2 during both RUN and POST, the EV is high, and the C1/C2 cell pair is said to be strongly reactivated.
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