Review
[Evidence of hormone replacement therapy for osteoporosis]
[Article in
Japanese]
Affiliations
- PMID: 18830040
Item in Clipboard
Review
[Evidence of hormone replacement therapy for osteoporosis]
[Article in
Japanese]
Clin Calcium.
2008 Oct.
Abstract
Postmenopausal bone estrogen deficiency causes rapid bone loss. Therefore hormone replacement therapy (HRT) has been considered as a rational therapy for postmenopausal not only for osteopenia but also osteoporosis. The results of Women's Health Initiative (WHI) hormone trial had given the strong restriction on HRT. However recent closer analyses have shown that HRT initiated for early menopausal women brings many benefits without elevation of the risks, and that the appropriate selection of dose level or a way to apply can also reduce the risks of HRT. HRT has many physiological effects that were not seen in other drugs and so HRT can be considered as one of the most effective treatment for postmenopausal osteoporosis.
Similar articles
-
Hormone replacement therapy in the post-Women's Health Initiative era. Report a a meeting held in Funchal, Madeira, February 24-25, 2003.Climacteric. 2003 May;6 Suppl 1:11-36. Climacteric. 2003. PMID: 12945798 Review.
-
[Daily practice using the guidelines for prevention and treatment of osteoporosis. Recent evidence of estrogen therapy for osteoporosis].Clin Calcium. 2008 Aug;18(8):1141-6. Clin Calcium. 2008. PMID: 18677052 Review. Japanese.
-
Postmenopausal osteoporosis and hormone replacement therapy.Minerva Med. 2004 Dec;95(6):507-20. Minerva Med. 2004. PMID: 15785435 Review. English, Italian.
-
[Hormone replacement therapy and osteoporosis].Clin Calcium. 2004 Mar;14(3):436-41. Clin Calcium. 2004. PMID: 15577004 Review. Japanese.
-
Climacteric medicine: European Menopause and Andropause Society (EMAS) 2004/2005 position statements on peri- and postmenopausal hormone replacement therapy.Maturitas. 2005 May 16;51(1):8-14. doi: 10.1016/j.maturitas.2005.02.019. Maturitas. 2005. PMID: 15883103
Cited by
-
Do estrogen and alendronate improve metaphyseal fracture healing when applied as osteoporosis prophylaxis?Calcif Tissue Int. 2010 Jan;86(1):23-32. doi: 10.1007/s00223-009-9318-7. Epub 2009 Dec 1. Calcif Tissue Int. 2010. PMID: 19949941 Free PMC article.
-
High-Throughput Metabolomics Discovers Metabolic Biomarkers and Pathways to Evaluating the Efficacy and Exploring Potential Mechanisms of Osthole Against Osteoporosis Based on UPLC/Q-TOF-MS Coupled With Multivariate Data Analysis.Front Pharmacol. 2020 May 20;11:741. doi: 10.3389/fphar.2020.00741. eCollection 2020. Front Pharmacol. 2020. PMID: 32670052 Free PMC article.