Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Sep 16;13(9):2190-219.
doi: 10.3390/molecules13092190.

Polyphenols in cocoa and cocoa products: is there a link between antioxidant properties and health?

Affiliations
Review

Polyphenols in cocoa and cocoa products: is there a link between antioxidant properties and health?

Abbe Maleyki Mhd Jalil et al. Molecules. .

Abstract

Cocoa and cocoa products have received much attention due to their significant polyphenol contents. Cocoa and cocoa products, namely cocoa liquor, cocoa powder and chocolates (milk and dark chocolates) may present varied polyphenol contents and possess different levels of antioxidant potentials. For the past ten years, at least 28 human studies have been conducted utilizing one of these cocoa products. However, questions arise on which of these products would deliver the best polyphenol contents and antioxidant effects. Moreover, the presence of methylxanthines, peptides, and minerals could synergistically enhance or reduce antioxidant properties of cocoa and cocoa products. To a greater extent, cocoa beans from different countries of origins and the methods of preparation (primary and secondary) could also partially influence the antioxidant polyphenols of cocoa products. Hence, comprehensive studies on the aforementioned factors could provide the understanding of health-promoting activities of cocoa or cocoa products components.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Basic structure of flavonols [34].
Figure 2
Figure 2
Structures the catechin and epicatechin enantiomers [34,46].
Figure 3
Figure 3
Structures of procyanidin dimer and trimer in cocoa [36].
Figure 4
Figure 4
Methyxanthines present in cocoa [86].

References

    1. Barry Callebaut. History of chocolates. 2008. http://www.barry-callebaut.com/1589.
    1. Dillinger T.L., Barriga P., Escarcega S., Jimenez M., Lowe D.S., Grivetti L.E. Food of the Gods: Cure for humanity? A cultural history of the medicinal and ritual use of chocolate. J. Nutr. 2000;130:2057S–2072S. - PubMed
    1. Kelm M.A., Johnson J.C., Robbins R.J., Hammerstone J.F., Schmitz H.H. High-performance liquid chromatography separation and purification of cacao (Theobroma cacao L.) procyanidins according to degree of polymerization using a diol stationary phase. J. Agric. Food Chem. 2006;54:1571–1576. doi: 10.1021/jf0525941. - DOI - PubMed
    1. Tomas-Barberan F.A., Cienfuegos-Jovellanos E., Marin A., Muguerza B., Gil Izquierdo A., Cerdaa B., Zafrilla P., Morillas J., Mulero J., Ibarra A., Pasamar M., Ramoan D., Espin J.C. A new process to develop a cocoa powder with higher flavonoid monomer content and enhanced bioavailability in healthy humans. J. Agric. Food Chem. 2007;55:3926–3935. doi: 10.1021/jf070121j. - DOI - PubMed
    1. Cooper K.A., Donovan J.L., Waterhouse A.L., Williamson G. Cocoa and health: a decade of research. Bri. J. Nutr. 2008;99:1–11. - PubMed