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Review
. 2008 Dec;84(6):734-40.
doi: 10.1038/clpt.2008.187. Epub 2008 Oct 1.

Personalized therapeutics: HIV treatment in adolescents

N Y Rakhmanina  1 , E V Capparelli, J N van den Anker
Affiliations
Review

Personalized therapeutics: HIV treatment in adolescents

N Y Rakhmanina et al. Clin Pharmacol Ther. 2008 Dec.

Erratum in

  • Clin Pharmacol Ther. 2009 Jan;85(1):110

Abstract

Adolescents infected with human immunodeficiency virus (HIV) represent a heterogeneous group of pubertal children and young adults. Antiretroviral therapy (ART) in adolescents is complex and depends on multiple factors. The continued use of higher (weight- or surface-based) pediatric doses can result in potentially toxic drug exposure, whereas early introduction of lower adult doses can lead to the development of drug resistance and virologic failure. The physiological and psychosocial changes during puberty create strong grounds for an individualized therapeutic approach in HIV-infected adolescents.

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Conflict of interest statement

CONFLICT OF INTEREST

E.V.C. is a DSMB Member of Pfizer Pharmaceuticals and a consultant for GlaxoSmithKline. The other authors declared no conflict of interest.

References

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