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. 2008 Oct 21:(39):4828-30.
doi: 10.1039/b809186b. Epub 2008 Aug 26.

Interaction of trivalent antimony with a CCHC zinc finger domain: potential relevance to the mechanism of action of antimonial drugs

Cynthia Demicheli  1 , Frédéric Frézard, John B Mangrum, Nicholas P Farrell
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Interaction of trivalent antimony with a CCHC zinc finger domain: potential relevance to the mechanism of action of antimonial drugs

Cynthia Demicheli et al. Chem Commun (Camb). .

Abstract

Sb(III) competes with Zn(II) for its binding to the CCHC zinc finger domain of the NCp7 protein of HIV-1, indicating that zinc finger proteins may be targets for antimony-based drugs and thus responsible for their important pharmacological actions.

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