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Review
. 2008 Dec;20(6):697-702.
doi: 10.1016/j.coi.2008.09.004. Epub 2008 Oct 14.

The IL-17 cytokine family and their role in allergic inflammation

Yui-Hsi Wang  1 , Yong-Jun Liu
Affiliations
Review

The IL-17 cytokine family and their role in allergic inflammation

Yui-Hsi Wang et al. Curr Opin Immunol. 2008 Dec.

Abstract

Allergic diseases and asthma has long been hypothesized as the results of the dysregulation of type 2 immune responses to environmental allergens. Recent progresses in characterizing the proinflammatory IL-17 cytokine family have added additional layer of complexity on the regulation of allergic inflammation. The delineation of IL-17-producing CD4+ T cell subset (Th17) has led to the revision of Th1/Th2 paradigm and impacts our perspectives on the basis of chronic tissue inflammation. In addition, the distinctive expression patterns and biological activities of individual IL-17 cytokine member may play different roles in the regulation of the pathogenesis of allergic diseases. Understanding the cellular source and targeting cells of IL-17 cytokine family member will provide the basis to elucidate the cellular mechanism underlying allergic inflammation and improve our therapeutic approaches for allergy.

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