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Comment

. 2008 Oct 7;105(40):15225-6.

doi: 10.1073/pnas.0808458105. Epub 2008 Oct 1.

Dissecting the role of cadherin-catenin proteins in mammalian epidermis

Wen-Hui Lien¹, Ewa Stepniak, Valeri Vasioukhin

Affiliations

PMID: 18832145
PMCID: PMC2563091
DOI: 10.1073/pnas.0808458105

Comment

Dissecting the role of cadherin-catenin proteins in mammalian epidermis

Wen-Hui Lien et al. Proc Natl Acad Sci U S A. 2008.

. 2008 Oct 7;105(40):15225-6.

doi: 10.1073/pnas.0808458105. Epub 2008 Oct 1.

Authors

Wen-Hui Lien¹, Ewa Stepniak, Valeri Vasioukhin

Affiliation

¹ Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

PMID: 18832145
PMCID: PMC2563091
DOI: 10.1073/pnas.0808458105

No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1. — Fig. 1.
Similar and distinct functions of cadherin–catenin proteins in skin epidermis. The schematic diagram shows connections between cadherin–catenin proteins and cellular phenotypes revealed by loss-of-function experiments. While cadherins appear to be primarily responsible for mechanical tissue integrity, catenins also are involved in regulation of multiple signal transduction pathways.

See this image and copyright information in PMC

Comment on

Loss of p120 catenin and links to mitotic alterations, inflammation, and skin cancer.
Perez-Moreno M, Song W, Pasolli HA, Williams SE, Fuchs E. Perez-Moreno M, et al. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15399-404. doi: 10.1073/pnas.0807301105. Epub 2008 Sep 22. Proc Natl Acad Sci U S A. 2008. PMID: 18809907 Free PMC article.
New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity.
Tinkle CL, Pasolli HA, Stokes N, Fuchs E. Tinkle CL, et al. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15405-10. doi: 10.1073/pnas.0807374105. Epub 2008 Sep 22. Proc Natl Acad Sci U S A. 2008. PMID: 18809908 Free PMC article.

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References

1. Lien WH, Klezovitch O, Vasioukhin V. Cadherin-catenin proteins in vertebrate development. Curr Opin Cell Biol. 2006;18:499–506. - PubMed
1. Halbleib JM, Nelson WJ. Cadherins in development: Cell adhesion, sorting, and tissue morphogenesis. Genes Dev. 2006;20:3199–3214. - PubMed
1. Perez-Moreno M, Song W, Pasolli HA, Williams SE, Fuchs E. Loss of p120 catenin and links to mitotic alterations, inflammation, and skin cancer. Proc Natl Acad Sci USA. 2008;105:15399–15404. - PMC - PubMed
1. Tinkle CL, Pasolli HA, Stokes N, Fuchs E. New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity. Proc Natl Acad Sci USA. 2008;105:15405–15410. - PMC - PubMed
1. Hartsock A, Nelson WJ. Adherens and tight junctions: Structure, function and connections to the actin cytoskeleton. Biochim Biophys Acta. 2008;1778:660–669. - PMC - PubMed

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