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Clinical Trial
. 2008 Oct 18;22(16):2207-9.
doi: 10.1097/QAD.0b013e32831392d4.

The therapeutic phase I trial of the recombinant native HIV-1 Tat protein

Barbara Ensoli  1 , Valeria Fiorelli, Fabrizio Ensoli, Adriano Lazzarin, Raffaele Visintini, Pasquale Narciso, Aldo Di Carlo, Paolo Monini, Mauro Magnani, Enrico Garaci
Affiliations
Clinical Trial

The therapeutic phase I trial of the recombinant native HIV-1 Tat protein

Barbara Ensoli et al. AIDS. .

Abstract

The native HIV-1 Tat protein was chosen as a vaccine candidate based on its key role in the virus life cycle and on the correlation of Tat-specific immune responses with the asymptomatic stage and lower disease progression rates, but also due to its sequence conservation amongst the various HIV clades as well as the adjuvant effects on dendritic cells. Safety, immunogenicity and efficacy data in monkeys support the development of this vaccine concept.

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