Review
doi: 10.1111/j.1600-0463.2008.01036.x.
In vivo real-time imaging of nuclear-cytoplasmic dynamics of dormancy, proliferation and death of cancer cells
Affiliations
- PMID: 18834414
- DOI: 10.1111/j.1600-0463.2008.01036.x
Item in Clipboard
Review
In vivo real-time imaging of nuclear-cytoplasmic dynamics of dormancy, proliferation and death of cancer cells
APMIS.
2008 Jul-Aug.
Abstract
The in vivo visualization of dormancy, proliferation, as well as cell death is of great importance in understanding the cellular pathology of cancer. We describe here the use of fluorescent proteins to differentially label cells in the nucleus and cytoplasm, and high-powered imaging technology to visualize the nuclear-cytoplasmic dynamics of these phenomena of cancer in vivo. The implications of this technology for discovery of new visible targets at the cellular level for treatment of cancer are discussed.
Similar articles
-
Cellular dynamics visualized in live cells in vitro and in vivo by differential dual-color nuclear-cytoplasmic fluorescent-protein expression.Cancer Res. 2004 Jun 15;64(12):4251-6. doi: 10.1158/0008-5472.CAN-04-0643. Cancer Res. 2004. PMID: 15205338
-
Development of real-time subcellular dynamic multicolor imaging of cancer-cell trafficking in live mice with a variable-magnification whole-mouse imaging system.Cancer Res. 2006 Apr 15;66(8):4208-14. doi: 10.1158/0008-5472.CAN-05-3927. Cancer Res. 2006. PMID: 16618743
-
Dual-color imaging of nuclear-cytoplasmic dynamics, viability, and proliferation of cancer cells in the portal vein area.Cancer Res. 2006 Jan 1;66(1):303-6. doi: 10.1158/0008-5472.CAN-05-2958. Cancer Res. 2006. PMID: 16397243
-
Real-time subcellular imaging in live animals: new visible targets for cancer drug discovery.IDrugs. 2006 Sep;9(9):632-5. IDrugs. 2006. PMID: 16952071 Review.
-
Fluorescent proteins as visible in vivo sensors.Prog Mol Biol Transl Sci. 2013;113:389-402. doi: 10.1016/B978-0-12-386932-6.00010-7. Prog Mol Biol Transl Sci. 2013. PMID: 23244796 Review.
Cited by
-
Review of tumor dormancy therapy using traditional oriental herbal medicine.J Pharmacopuncture. 2013 Mar;16(1):12-20. doi: 10.3831/KPI.2013.16.005. J Pharmacopuncture. 2013. PMID: 25780657 Free PMC article. Review.
-
Suppression and activation of the malignant phenotype by extracellular matrix in xenograft models of bladder cancer: a model for tumor cell "dormancy".PLoS One. 2013 May 24;8(5):e64181. doi: 10.1371/journal.pone.0064181. Print 2013. PLoS One. 2013. PMID: 23717563 Free PMC article.
-
Extended-working-distance multiphoton micromanipulation microscope for deep-penetration imaging in live mice and tissue.J Biomed Opt. 2009 Mar-Apr;14(2):024032. doi: 10.1117/1.3103783. J Biomed Opt. 2009. PMID: 19405761 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
