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Case Reports
. 2008 Sep;31(9):1229-32.
doi: 10.1111/j.1540-8159.2008.01169.x.

Nifekalant and disopyramide in a patient with short QT syndrome: evaluation of pharmacological effects and electrophysiological properties

Masahiro Mizobuchi  1 , Yoshihisa Enjoji, Ryuji Yamamoto, Tsuyoshi Ono, Atsushi Funatsu, Daisuke Kambayashi, Tomoko Kobayashi, Shigeru Nakamura
Affiliations
Case Reports

Nifekalant and disopyramide in a patient with short QT syndrome: evaluation of pharmacological effects and electrophysiological properties

Masahiro Mizobuchi et al. Pacing Clin Electrophysiol. 2008 Sep.

Abstract

We assessed several pharmacological effects on electrocardiogram parameters and effective refractory period (ERP) in a patient with a short QT syndrome (SQTS). Pharmacological challenge tests revealed that disopyramide and selective I(kr) blocker, nifekalant normalized QT interval, and ERP of the atrial and ventricular myocardium. This study suggested that disopyramide and nifekalant should be feasible for the drug treatment of the SQTS. Moreover, QT interval was paradoxically prolonged at higher heart rates induced with isoproterenol infusion or an exercise test, although the mechanism of this QT prolongation remains to be investigated.

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