Going with the flow: JAK-STAT signaling in JMML
- PMID: 18835028
- DOI: 10.1016/j.ccr.2008.09.006
Going with the flow: JAK-STAT signaling in JMML
Abstract
Knowledge of the distinctive cellular and genetic traits of a cancer aids in diagnosis, prognosis, and potentially treatment. In this issue of Cancer Cell, Kotecha et al. (2008) demonstrate using a sophisticated flow cytometry approach that signal transduction responses to exogenous stimulation can inform diagnosis and pathobiology of myeloproliferative neoplasms.
Comment on
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Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates.Cancer Cell. 2008 Oct 7;14(4):335-43. doi: 10.1016/j.ccr.2008.08.014. Cancer Cell. 2008. PMID: 18835035 Free PMC article.
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