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. 2008 Oct 15;18(20):5456-9.
doi: 10.1016/j.bmcl.2008.09.028. Epub 2008 Sep 11.

'Reverse' alpha-ketoamide-based p38 MAP kinase inhibitors

Antonio Garrido Montalban  1 , Erik Boman, Chau-Dung Chang, Susana Conde Ceide, Russell Dahl, David Dalesandro, Nancy G J Delaet, Eric Erb, Andrew Gibbs, Jeff Kahl, Linda Kessler, Jan Lundström, Stephen Miller, Hiroshi Nakanishi, Ed Roberts, Eddine Saiah, Robert Sullivan, Zhijun Wang, Christopher J Larson
Affiliations

'Reverse' alpha-ketoamide-based p38 MAP kinase inhibitors

Antonio Garrido Montalban et al. Bioorg Med Chem Lett. .

Abstract

We have identified a second series of potent p38 inhibitors. As with our first generation series, these compounds are based on an alpha-ketoamide scaffold. The reversal of the ketoamide order, however, introduces more chemical flexibility and in addition results in improve potencies against p38.

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