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. 2008 Oct 29;582(25-26):3614-8.
doi: 10.1016/j.febslet.2008.09.040. Epub 2008 Oct 1.

Ascorbic acid is a regulator of the intracellular cAMP concentration: old molecule, new functions?

F Kaya  1 , S Belin, Gr Diamantidis, M Fontes
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Free article

Ascorbic acid is a regulator of the intracellular cAMP concentration: old molecule, new functions?

F Kaya et al. FEBS Lett. .
Free article

Abstract

Recently, using an animal model of Charcot-Marie-Tooth human disorder, we showed that ascorbic acid (AA) represses PMP22 gene expression by acting on intracellular cAMP concentrations. In this work, we present kinetics data on the inhibitory effect of AA upon adenylate cyclase activity. The data show that this molecule acts as a competitive inhibitor of the enzyme, a finding that opens new pharmacological avenues.

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