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. 2009 Feb;11(2):116-24.
doi: 10.1016/j.jfms.2008.02.010. Epub 2008 Oct 2.

Feline thyroid carcinoma: diagnosis and response to high-dose radioactive iodine treatment

Angie Hibbert  1 , Tim Gruffydd-Jones, Esther L Barrett, Michael J Day, Andrea M Harvey
Affiliations

Feline thyroid carcinoma: diagnosis and response to high-dose radioactive iodine treatment

Angie Hibbert et al. J Feline Med Surg. 2009 Feb.

Abstract

This study reports the scintigraphy, histopathology, sole treatment with high-dose radioactive iodine and outcome of eight cases of feline thyroid carcinoma. Scintigraphic findings were variable and in 7/8 cases scintigraphic features could not reliably distinguish whether the thyroid tissue was malignant. Histopathology revealed typical criteria of malignancy in all cases, with mitotic activity described most frequently (7/8 cases), followed by infiltration of local tissues (4/8 cases). Cellular pleomorphism was infrequently observed. Single high-dose (1100MBq I(131)) radioiodine therapy was successful in 6/8 cases, with complete resolution of hyperthyroidism, and was associated with prolonged survival times (181-2381 days). Sole treatment with high-dose radioiodine is a safe and effective treatment for functional thyroid carcinoma. The prognosis for feline thyroid carcinoma successfully treated with radioiodine is good, with extended survival times commonly achieved.

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Figures

Fig 1.
Fig 1.
Case 6. Scintigraphic image – single cervical area of IRU.
Fig 2.
Fig 2.
Case 8. Scintigraphic images of an NHS functional carcinoma. (a) Pre-radioiodine treatment demonstrating a single cervical region of IRU. (b) Post-treatment scan revealed no further radioisotope uptake.
Fig 3.
Fig 3.
Case 5. Scintigraphic image – large hyperfunctional bilobed area of IRU extending from cervical region to thoracic inlet.
Fig 4.
Fig 4.
Case 4. Scintigraphic image – five discrete regions of IRU; three cervical and two intrathoracic.
Fig 5.
Fig 5.
(a) Case 1 scintigraphic image – two discrete cervical regions of IRU and diffuse pulmonary uptake consistent with pulmonary metastases. (b) Case 1, thoracic radiograph (right lateral view) demonstrating diffuse bronchointerstitial pulmonary pattern.
Fig 6.
Fig 6.
Section from thyroid carcinoma in case 2. There is invasion of muscle by lobules of well-differentiated thyroid follicular epithelial cells forming colloid-filled acinar units. Haematoxylin and eosin. Bar, 200 μm.
Fig 7.
Fig 7.
Section from thyroid carcinoma in case 8. A solid lobule of neoplastic thyroid epithelial cells infiltrates peri-thyroidal muscle. The cells comprising this lobule are uniform with packetting by fine connective tissue septae. Haematoxylin and eosin. Bar, 200 μm.
See this image and copyright information in PMC

References

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