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Review
. 2009 Jan;1788(1):184-93.
doi: 10.1016/j.bbamem.2008.09.001. Epub 2008 Sep 12.

Glycosphingolipid behaviour in complex membranes

Alessandro Prinetti  1 , Nicoletta Loberto, Vanna Chigorno, Sandro Sonnino
Affiliations
Free article
Review

Glycosphingolipid behaviour in complex membranes

Alessandro Prinetti et al. Biochim Biophys Acta. 2009 Jan.
Free article

Abstract

Glycosphingolipids, due to their tendency to form laterally separated liquid-ordered phases, possess a high potential for the creation of order in biological membranes. The formation of glycosphingolipid-rich domains within the membrane has profound consequences on the membrane organization at different levels, and on the conformational and biological properties of membrane-associated proteins and multimolecular protein complexes. In this review, we will discuss 1) how glycosphingolipids influence the lateral organization of biological membranes; 2) how glycosphingolipids influence the function of membrane-associated proteins.

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