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Randomized Controlled Trial
. 2009 Feb;11(2):125-30.
doi: 10.1016/j.jfms.2008.06.009. Epub 2008 Oct 1.

Effects of diet on glucose control in cats with diabetes mellitus treated with twice daily insulin glargine

Tanya D Hall  1 , Orla Mahony, Elizabeth A Rozanski, Lisa M Freeman
Affiliations
Randomized Controlled Trial

Effects of diet on glucose control in cats with diabetes mellitus treated with twice daily insulin glargine

Tanya D Hall et al. J Feline Med Surg. 2009 Feb.

Abstract

The purpose of this study was to evaluate the effects of dietary modification in addition to twice daily insulin glargine. Cats were treated with insulin glargine twice daily and randomized to receive either a low carbohydrate, high protein (LCHP) diet (n=6) or a control diet (n=6) for 10 weeks. Re-evaluations of clinical signs, blood glucose curves, and serum fructosamine concentrations were performed at weeks 1, 2, 4, 6, and 10. Two of 12 cats achieved complete remission by the end of the study but remission rate was not different between diet groups. Using twice daily insulin glargine and frequent monitoring, all cats in both diet groups achieved successful glycemic control. Frequent monitoring is key to achieving glycemic control in diabetic cats; potential benefits of dietary modification require further evaluation.

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Figures

Fig 1.
Fig 1.
Fructosamine concentrations at baseline (week 0) and weeks 1, 2, 4, 6, and 10 in cats with DM treated with insulin glargine and randomized to receive either a LCHP diet (open bars) or a control diet (closed bars). Over the entire course of the study, there was a significantly greater decrease in fructosamine concentrations for the LCHP group compared to the control group (P=0.01).
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