doi: 10.1016/0167-4781(91)90041-j.
Hepatic and renal expression of rat apolipoprotein E under control of the metallothionein promoter in transgenic mice
Affiliations
- PMID: 1883846
- DOI: 10.1016/0167-4781(91)90041-j
Item in Clipboard
Hepatic and renal expression of rat apolipoprotein E under control of the metallothionein promoter in transgenic mice
Biochim Biophys Acta.
.
Abstract
We created three lines of transgenic mice with an integrated rat genomic apolipoprotein E gene fused with the mouse metallothionein I promoter. These lines transcribed rat apoE mRNA in the liver and/or in the kidney and expressed significant amounts of rat apoE in plasma. Enhancement of the plasma level by treatment with Zn ion or Bi ion was observed.
Similar articles
-
Retinyl ester storage is normal in transgenic mice with enhanced expression of cellular retinol-binding protein type I.J Nutr. 1996 Nov;126(11):2709-19. doi: 10.1093/jn/126.11.2709. J Nutr. 1996. PMID: 8914940
-
Developmental variation in copper, zinc and metallothionein mRNA in brindled mutant and nutritionally copper deficient mice.Biochim Biophys Acta. 1991 Oct 21;1097(3):205-11. doi: 10.1016/0925-4439(91)90036-9. Biochim Biophys Acta. 1991. PMID: 1681908
-
Differential expression of the metallothionein gene in liver and brain of mice and rats.Toxicol Appl Pharmacol. 1993 Mar;119(1):1-10. doi: 10.1006/taap.1993.1037. Toxicol Appl Pharmacol. 1993. PMID: 8470112
-
Discovery of a brain promoter from the human transferrin gene and its utilization for development of transgenic mice that express human apolipoprotein E alleles.Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12115-9. doi: 10.1073/pnas.92.26.12115. Proc Natl Acad Sci U S A. 1995. PMID: 8618855 Free PMC article.
-
Transgenic mouse and gene therapy.Diabetes. 1996 Jul;45 Suppl 3:S129-32. doi: 10.2337/diab.45.3.s129. Diabetes. 1996. PMID: 8674880
Cited by
-
Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease.J Neurosci. 2004 Apr 14;24(15):3801-9. doi: 10.1523/JNEUROSCI.5543-03.2004. J Neurosci. 2004. PMID: 15084661 Free PMC article.
-
Testis-specific expression of a metallothionein I-driven transgene correlates with undermethylation of the locus in testicular DNA.Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):8886-90. doi: 10.1073/pnas.90.19.8886. Proc Natl Acad Sci U S A. 1993. PMID: 8415626 Free PMC article.
-
Overexpression of apolipoprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia.Proc Natl Acad Sci U S A. 1992 Mar 1;89(5):1750-4. doi: 10.1073/pnas.89.5.1750. Proc Natl Acad Sci U S A. 1992. PMID: 1542669 Free PMC article.
-
Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall.J Clin Invest. 1995 Feb;95(2):469-76. doi: 10.1172/JCI117687. J Clin Invest. 1995. PMID: 7860728 Free PMC article.
-
Secretion-recapture process of apolipoprotein E in hepatic uptake of chylomicron remnants in transgenic mice.J Clin Invest. 1994 May;93(5):2215-23. doi: 10.1172/JCI117218. J Clin Invest. 1994. PMID: 8182153 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Miscellaneous
