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. 1991 Jun;2(6):467-77.
doi: 10.1091/mbc.2.6.467.

Localization of transforming growth factor-beta 1 in mitochondria of murine heart and liver

U I Heine  1 , J K Burmester, K C Flanders, D Danielpour, E F Munoz, A B Roberts, M B Sporn
Affiliations

Localization of transforming growth factor-beta 1 in mitochondria of murine heart and liver

U I Heine et al. Cell Regul. 1991 Jun.

Abstract

Using both electron microscopic immunohistochemistry and cell fractionation techniques, we show that transforming growth factor-beta 1 (TGF-beta 1) is found in mitochondria of rat and mouse cardiac myocytes and rat hepatocytes. Four different polyclonal antibodies, raised against various epitopes encompassing the mature portion of the TGF-beta 1 molecule as well as the pro-region of its precursor, were used for the electron microscopy studies. The localization of TGF-beta 1 in mitochondria was confirmed by detection of the native peptide in mitochondria isolated from rat heart and liver; the majority of native TGF-beta 1 found in liver homogenates was recovered in highly pure mitochondrial fractions. The functional role of TGF-beta in the mitochondrion is unknown at present.

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