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. 2008 Nov;115(11):1573-85.
doi: 10.1007/s00702-008-0119-3. Epub 2008 Oct 7.

Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies

Klaus-Peter Lesch  1 , Nina Timmesfeld, Tobias J Renner, Rebecca Halperin, Christoph Röser, T Trang Nguyen, David W Craig, Jasmin Romanos, Monika Heine, Jobst Meyer, Christine Freitag, Andreas Warnke, Marcel Romanos, Helmut Schäfer, Susanne Walitza, Andreas Reif, Dietrich A Stephan, Christian Jacob
Affiliations

Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies

Klaus-Peter Lesch et al. J Neural Transm (Vienna). 2008 Nov.

Abstract

A genome-wide association (GWA) study with pooled DNA in adult attention-deficit/hyperactivity disorder (ADHD) employing approximately 500K SNP markers identifies novel risk genes and reveals remarkable overlap with findings from recent GWA scans in substance use disorders. Comparison with results from our previously reported high-resolution linkage scan in extended pedigrees confirms several chromosomal loci, including 16q23.1-24.3 which also reached genome-wide significance in a recent meta-analysis of seven linkage studies (Zhou et al. in Am J Med Genet Part B, 2008). The findings provide additional support for a common effect of genes coding for cell adhesion molecules (e.g., CDH13, ASTN2) and regulators of synaptic plasticity (e.g., CTNNA2, KALRN) despite the complex multifactorial etiologies of adult ADHD and addiction vulnerability.

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