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Comment
. 2008 Oct;8(4):275-6.
doi: 10.1016/j.cmet.2008.09.001.

Autophagy: a sweet process in diabetes

Alfred J Meijer  1 , Patrice Codogno
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Free article
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Autophagy: a sweet process in diabetes

Alfred J Meijer et al. Cell Metab. 2008 Oct.
Free article

Abstract

Autophagy is inhibited by the insulin-amino acid-mTOR signaling pathway. Two papers in this issue of Cell Metabolism (Ebato et al., 2008; Jung et al., 2008) provide evidence that basal autophagy is necessary to maintain the architecture and function of pancreatic beta cells and that its induction in diabetic mice protects beta cells against damage by oxidative stress.

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