Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1991 Jul 27;303(6796):219-20.
doi: 10.1136/bmj.303.6796.219.

Efficacy of fixed minidose warfarin prophylaxis in total hip replacement

M J Fordyce  1 , A S Baker, G E Staddon
Affiliations
Clinical Trial

Efficacy of fixed minidose warfarin prophylaxis in total hip replacement

M J Fordyce et al. BMJ. .

Abstract

Objective: To determine whether a small fixed perioperative dose of warfarin would prevent deep vein thrombosis after total hip replacement.

Design: Prospective, randomised, double blind placebo controlled trial.

Setting: Winford Orthopaedic Hospital, Bristol.

Subjects: 148 patients having primary total hip replacement.

Intervention: Warfarin 1 mg given daily for one week before and three weeks after surgery.

Main outcome measure: Deep vein thrombosis diagnosed by the iodine-125 labelled fibrinogen uptake method.

Results: Deep vein thrombosis occurred in 25 (34%) of the patients given warfarin and 19 (26%) of the controls (difference 8%; 95% confidence interval -6.8% to 22.8%).

Conclusion: Fixed minidose warfarin does not prevent deep vein thrombosis after total hip replacement.

PubMed Disclaimer

References

    1. Lancet. 1959 Dec 5;2(7110):981-9 - PubMed
    1. Br Med J (Clin Res Ed). 1987 Nov 21;295(6609):1309-12 - PubMed
    1. Br J Hosp Med. 1989 Oct;42(4):282-4 - PubMed
    1. J Bone Joint Surg Br. 1988 Jan;70(1):150 - PubMed
    1. J Bone Joint Surg Am. 1984 Dec;66(9):1388-93 - PubMed

Publication types

LinkOut - more resources