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. 2008 Oct;79(4):636-42.

Burden of cerebral malaria in central India (2004-2007)

Vidhan Jain  1 , Avinash C Nagpal, Pradeep K Joel, Manmohan Shukla, Mrigendra P Singh, Rasik B Gupta, Aditya P Dash, Saroj K Mishra, Venkatachalam Udhayakumar, Jonathan K Stiles, Neeru Singh
Affiliations

Burden of cerebral malaria in central India (2004-2007)

Vidhan Jain et al. Am J Trop Med Hyg. 2008 Oct.

Abstract

A study on the clinicoepidemiology of cerebral malaria (CM) and mild malaria (MM) among adults and children attending NSCB medical college hospital Jabalpur and civil hospital Maihar, Satna, in central India was undertaken. Of 1,633 patients, 401 were Plasmodium falciparum and 18 P. vivax. Of 401, 199 CM patients and 112 MM patients were enrolled. Severe complications among CM patients were jaundice (26%), acute renal failure (22%), respiratory distress (22%), severe malaria anemia (18%), hypotension (17%), hepatic encephalopathy (7.0%), and hematuria (5%). Among CM cases, seizures and severe malaria anemia were significantly higher in children (P < 0.0001) compared with adults, whereas jaundice (P < 0.0025), acute renal failure (P < 0.0001), and hematuria (P <or= 0.05) were significantly higher among adults. Mortality was high among adults with multiple organ failures. Overall case fatality rate was 21%. Neurologic sequelae at discharge from the hospital were 3%, whereas at follow-up, only 1% had persistent neurologic sequelae.

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Figures

FIGURE 1
FIGURE 1
A, Map of India showing Madhya Pradesh state. B, Madhya Pradesh state showing study site. C, Civil Hospital, Maihar district, Satna. D, NSCB Medical College, district, Jabalpur.
Flow Chart
Flow Chart
FIGURE 2
FIGURE 2
Complications by age group among CM patients admitted in Medical College, Jabalpur, and Civil Hospital Maihar, Satna.
FIGURE 3
FIGURE 3
Time of recovery after admission (in days) among adults and children.
See this image and copyright information in PMC

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