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. 2009 Jan;32(1):45-7.
doi: 10.2337/dc08-0808. Epub 2008 Oct 7.

Effect of a successful intensive lifestyle program on insulin sensitivity and glucose tolerance in obese youth

Melissa Shaw  1 , Mary Savoye, Anna Cali, James Dziura, William V Tamborlane, Sonia Caprio
Affiliations

Effect of a successful intensive lifestyle program on insulin sensitivity and glucose tolerance in obese youth

Melissa Shaw et al. Diabetes Care. 2009 Jan.

Abstract

Objective: To evaluate the impact on glucose metabolism of a lifestyle program (the Yale Bright Bodies Program) for obese children.

Research design and methods: Thirteen Bright Bodies and ten clinic-care control subjects who were part of a large randomized clinical trial had 75-g oral glucose tolerance tests at the beginning and end of the 12-month study.

Results: Bright Bodies subjects had significantly greater decreases in weight, BMI, and body fat than clinic-care subjects, and the Bright Body subjects' changes in body composition were accompanied by marked improvements in insulin sensitivity (P = 0.009) and glucose tolerance (P = 0.04).

Conclusions: An intensive lifestyle program that successfully reduces body weight and body fat can markedly improve insulin sensitivity and glucose metabolism in obese youth.

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References

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