Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Nov 13;51(21):7005-9.
doi: 10.1021/jm800537a. Epub 2008 Oct 9.

Potential nicotinic acetylcholine receptor ligands from 2,4-methanoproline derivatives

Anup B Patel  1 , John R Malpass
Affiliations

Potential nicotinic acetylcholine receptor ligands from 2,4-methanoproline derivatives

Anup B Patel et al. J Med Chem. .

Abstract

Potential nicotinic acetylcholine receptor (nAChR) ligands have been synthesized in which a methylisoxazole substituent is attached to the 1-position ( 26) of the 2-azabicyclo[2.1.1]hexane ring system or separated by "spacer" atoms ( 21 and 23). With ABT-594 as a model, a range of pyridine heterocycles have been attached to the 1-position via a -CH 2O- spacer ( 11, 14, and 6). The biological evaluation of target compounds showed there was no binding affinity at the alpha4beta2 and alpha3beta4 nAChR subtypes.

PubMed Disclaimer